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Do not miss the chance to find love today as a Muslim local single near Griffin!The objective of this proposal is to prepare fibril-forming peptides, containing the HET0017.HET0018.HET0019.HET0020 tet ptide of human amyloid beta-protein (ABeta) in the amyloid fibrils associated with Alzheimer's disease. Fibril-forming peptides contain the beta-strand (beta-sheet) stabilizing tet ptide sequences found in amyloidogenic proteins. Fibril-forming design peptides are useful probes of beta-sheet structure, and have the potential to inhibit fibrillogenesis by destabilizing the beta sheet structure. These fibril-forming design peptides are the basis of the present work. The specific aim is to synthesize and characterize fibril-forming peptides, comprising the HET0017.HET0018.HET0019.HET0020 tet ptide and examine their beta-sheet structure. Such beta-sheet structure can be stabilized in the design peptides by an insertion of charged amino acids in the tet ptides. This strategy should be useful for inhibiting the deposition of A? in Alzheimer's disease. This methodology also has the potential to be used for inhibiting Alzheimer-related amyloidogenesis by stabilization of other amyloidogenic sequences in unrelated proteins.

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